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Glio-Vascular Imaging Group

NCMM-EMBL Group Leader - Dr. Erlend A. Nagelhus

Dr. Nagelhus` research team at NCMM explores roles of astrocytes in neurological disorders by in vivo two-photon laser scanning microscopy. This minimally invasive technique offers real-time imaging of physiological and pathophysiological processes in the brain of living animals. Through a cranial window or the thinned skull, we study the dynamics of neuronal and glial calcium signalling, cell morphology, metabolism and cerebral blood flow.
 

In vivo two-photon imaging of astroglial Ca2+ signals during hypoosmotic stress (Thrane et al, 2011. PNAS 108(2):846-51).
In vivo two-photon imaging of astroglial Ca2+ signals during osmotically induced brain edema.
(Thrane et al, 2011. PNAS 108(2):846-51).
See free full text article and research highlight in Nat. Rev. Neurosci.

 
Currently, we are using gene knockout strategies to study the roles of glial aquaporins and associated molecules in extracellular volume dynamics, synaptic transmission and signaling at the blood-brain interface. The overall aim is to gain insight into mechanisms by which glia communicate with neurons and the vasculature. Understanding neuronal-glial-vascular interactions may provide new treatment strategies for brain disorders with perturbed circulation and water homeostasis.

Nagelhus is Professor in Physiology and runs the neuroimaging activity in Letten Centre at the Institute of Basic Medical Sciences, Domus Medica, Sognsvannsveien 9.
 

Group Members

Group Leader

Senior engineer 

Erlend A. Nagelhus

P. Johannes Helm

 
Researchers Vidar Jensen
  Anna E. Thoren
Postdocs John M. Burkhardt
   Karolina Szokol*
  Wannan Tang
PhD students Vigdis Andersen Eidsvaag*
 
Martine Eilert-Olsen
 
Rune Enger
  Gry Fluge Vindedal
Medical students    Cecilie E. Bugge
Alumni Nadia Nabil Haj-Yasein (completed PhD in 2012)
  Alexander Stanley Thrane (completed PhD in 2013)
 

Vinita Rangroo Thrane (completed PhD in 2013)

Georg Andreas Gundersen (completed PhD in 2013)

 

Photos and contact information for group members.

Publications

Selected publications

  1. Nagelhus EA, Ottersen OP (2013) Physiological roles of aquaporin-4 in brain. Physiol. Rev. (In Press).
  2. Thrane AS, Rangroo Thrane V, Zeppenfeld D, Lou N, Xu Q, Nagelhus EA, Nedergaard, M (2013) General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex. Proc Natl Acad Sci USA 109: 18974-9.
  3. Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Nagelhus EA, Nedergaard M (2012). A brain-wide glio-vascular pathway facilitates the clearance of interstitial solutes including amyloid β. Science Translational Medicine 15;4(147):147ra111.
  4. Haj-Yasein NN, Vindedal GF, Eilert-Olsen M, Gundersen GA, Skare Ø, Laake P, Klungland A, Thorén AE, Burkhardt JM, Ottersen OP, Nagelhus EA (2011). Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet. Proc Natl Acad Sci U S A 108(43):17815-20.
  5. Thrane AS, Rappold PM, Fujita T, Penja AT, Bekar L, Enger R, Haj-Yasein NN, Rangroo V, Skare O, Klungland A, Holen T, Ottersen OP, Nedergaard M, and Nagelhus EA (2011) Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A 108(2):846-51.
  6. Nagelhus EA, Horio Y, Inanobe A, Fujita A, Haug FM, Nielsen S, Kurachi Y, Ottersen OP. Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Muller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains. Glia 26:47-54, 1999
  7. Nielsen S*, Nagelhus EA*, Amiry-Moghaddam M, Bourque C, Agre P, Ottersen OP (1997). Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci. 17:171-80. *Nielsen and Nagelhus contributed equally.

Full list of Dr. Nagelhus's publications.

* Karolina Szokol and Vigdis Andersen Eidsvaag are associated members, employed at OUS Rikshospitalet (Taubøll Group and Eide Group, respectively)

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Published Aug 29, 2011 02:47 PM - Last modified Jun 6, 2014 11:26 AM
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